You can connect the Thinklabs One to a computer using a USB audio device. Directions for connecting the One via USB are attached to this article. Follow these instructions carefully and you will achieve excellent results.
While the computer's built-in audio input or headset jack can work, the quality of audio varies between computers. We strongly recommend the Audio Technica ATR2USB device. Most other USB audio devices connect to the One in a similar manner; however, very few have the audio quality needed for clinical auscultation.